广西医科大学学报2011，Vol.28Issue(3)：385-387,3.
血清白蛋白、球蛋白与慢性乙型病毒性肝炎病理的相关性研究
A STUDY ON THE CORRELATION OF SERUM ALBUMIN AND GLOBULIN WITH HEPAT- IC PATHOLOGY IN CHRONIC HEPATITIS B
摘要
Abstract
Objective:To study the correlation of serum albumin(ALB) and globulin(GLO) and albumin/ globulin(A/G) ratio with hepatic inflammatory activity and fibrosis stage in patients with chronic hepatitis B. Methods: Serum albumin and globulin were measured in 102 patients with chronic hepatitis B. Meanwhile the liver biopsies were performed in all patients, and the hepatic inflammatory activity grade and fibrosis stage were evaluated. The correlation of serum albumin with liver histopathology were analyzed. Results:① Serum albumin and A/G ratio were negatively correlated with inflammatory activity grade of liver ( r =-0. 405, P ＜0.001)and (r =-0.400, P ＜0. 001); repectively, and negatively correlated with fibrosis stage (r =-0.356, P ＜0.01)and (r=- 0. 271, P ＜ 0.01); respectively. ② Serum globulin was positively correlated with inflammatory activity grade ( r =0. 221, P ＜0.05). There was no significant correlation between serum globulin and fibrosis stage. ③Between low(＜2) and high(≥2) inflammatory activity and fibrosis stage, there was significant difference in serum albumin and A/G ratio. Conclusion: Serum albumin, globulin and A/G ratio can be used as the reference indexes for estimating hepatic inflammatory activity grade and fibrosis stage,serum albumin is more sensitive than globulin in estimating fibrosis stage in patients with chronic hepatitis B.关键词
白蛋白/球蛋白/慢性乙型病毒性肝炎/炎症活动度/纤维化Key words
serum albumin/globulin/ chronic hepatitis B/ inflammatory activity/ fibrosis分类
医药卫生引用本文复制引用
韦麒,苏明华,江建宁,刘志红,马韵,蒙达礼,黄小红..血清白蛋白、球蛋白与慢性乙型病毒性肝炎病理的相关性研究[J].广西医科大学学报,2011,28(3):385-387,3.基金项目
广西自然科学基金资助项目(No.桂科青 0832037 （）
No.桂科自0832117 2010GXNSFD013046) （）
