陕西医学杂志2011，Vol.40Issue(7)：787-790,4.
IL-10防治创伤后感染继发DIC作用机制研究
Research of the function of IL-10 to prevent and cure DIC induced by trauma combined infection
摘要
Abstract
Objective :To research the function af IL-10 (interleukin-10) in DIC induced by trauma combined infection , and using IL-10 or IL-10-antibody to prevent and cure DIC in the different phase.Methods :After the rabbit model of DIC effected by trauma combin -ed infection constructed, PT, APTT, FIB, PLT and D-dimer of the rabbits were tested by Diagnostica Stago SAS and the level of IL-10 were tested by ELISA (enzyme linked immunosorb -ent assay) in the different time.When IL-10 or anti-IL-10 antibody were used to treat DIC in the different phase, the Level of TNF-a , IL-1 or the different diagnose index of DIC were tested so as to realize the function of IL-10 how to prevent and cure DIC.Results : APTT of the rabbit of DIC effected by trauma combined with infection were obviously longer than that in the control after 6～24h.Along with the time expanding, the value of PLT descended gradually, on the other hand, the value of D-dimer increased gradually.The level of IL-10 had a trend of increasing gradu -ally within 2～6 hours and soon up to steady level The level of TNF-a and IL-1 could be reduced by preventively using IL-10 in the prophase of DIC,meanwhile the level of IL-10 could be reduced by using anti-IL-10 antibody in the developmental phase of DIC.Conclusion;In the prophase of DIC effected by trauma combined with infection the level of IL-10 was lacking relatively, but in the developmental phase it was overabundant.Maladjustment of IL-10 was one of the reasons of leading to the development of DIC.Preventively using IL-10 in the prophase of DIC or using anti-IL-10 antibody in the developmental phase of DIC maybe have positive function to treat DIC.关键词
弥漫性血管内凝血/预防和控制/创伤和损伤/白细胞介素10/治疗应用/兔Key words
Disseminated imtravoscular coagulation/prevention control/ Wounds and injuries Interleukin-10/therapeutic use/ Rabbits分类
医药卫生引用本文复制引用
王玮,林国强,李楠楠,杜艳..IL-10防治创伤后感染继发DIC作用机制研究[J].陕西医学杂志,2011,40(7):787-790,4.基金项目
福建省青年人才基金项目(No.2006F3149) （No.2006F3149）
南京军区"十一五"课题资助项目(No.06MA94) （No.06MA94）
