实用临床医药杂志2011，Vol.15Issue(11)：8-10,3.
卵巢上皮性肿瘤组织中黏蛋白抗原4和核因子-κB/p65蛋白表达及临床意义
The clinical significance of MUC4 and NF-κB/p65 expression in ovarian epithelial tumor
徐信兰 1张玲玲 2卢丹 3孔祥3
作者信息
- 1. 江苏省泰州市人民医院,妇科,江苏,泰州,225300
- 2. 江苏省扬州市第一人民医院,妇科,江苏,扬州,225001
- 3. 扬州大学临床医学院,妇产科,江苏,扬州,225001
- 折叠
摘要
Abstract
Objective To investigate the expression and clinical significance of MUC4 and NF - κB/p65 proteins in epithelial ovarian carcinoma. Methods Ovarian epithelial tumor and normal ovarian tissue were detected and analyzed for their MUC4 and NF - Kb/p65 protein expression level with immunohistochemical method, and the paraffin -embedded tissue sections were incubated with anti -muc4 antibody and anti - NF - κB/p65 antibody. Results The positive rate of muc4 protein and NF - κB/p65 protein expression in malignant epithelial tumors was 80％ and 92.30％ respectively. The statistical evaluation showed that the expression of muc4 and NF - κB/p65 protein had a close relation with histological differentiation and lymph node metastasis in epithelial ovarian carcinoma (p ＜0.05). Conclusion Muc4 protein and NF - κB/p65 protein is high expression in ovarian carcinoma, Muc4 and NF - Kb/p65 protein expression is closely correlated with the ovarian tumor histological differentiation and lymph node metastasis. Muc4 could be a potential candidate marker for early detection of epithelial ovarian carcinoma.关键词
卵巢癌,上皮性/黏蛋白抗原4/核因子-κBκ/p65/免疫组化Key words
MUC4/ NF- κB/p65/ carcinoma, ovarian, epithelial immunohistochemistry分类
医药卫生引用本文复制引用
徐信兰,张玲玲,卢丹,孔祥..卵巢上皮性肿瘤组织中黏蛋白抗原4和核因子-κB/p65蛋白表达及临床意义[J].实用临床医药杂志,2011,15(11):8-10,3.
