实用临床医药杂志2011，Vol.15Issue(11)：15-18,4.
人端粒酶逆转录酶与p53蛋白在甲状腺癌组织中的表达、相关性及临床意义
The expression, correction and clinical significance of hTERTmRNA and p53 protein in thyroid carcinoma
常青 1陈春悠 1胡耀杰1
作者信息
- 1. 河北省唐山市工人医院,头颈外科,河北,唐山,063000
- 折叠
摘要
Abstract
Objective To explore the expression, correction and clinical significance of hTERTmRNA and p53 protein in thyroid carcinoma. Methods The expression of hTERTmRNA was detected by in situ hybridization, and the expression of mutant p53 protein was detected by immunohistochemistry. Results ① Overexpression of hTERTrnRNA and mutant p53 protein were indicated in thyroid carcinoma tissue (P＜0.05). ② The positive-staining rate of hTERTmRNA and mutant p53 protein were related to the different pathology classification, tumor stages, positive or negative metastasis lymph nodes (P＜0.05). It was not related to the age and sex of patients (P ＞ 0. 05 ). ③ It demonstrated a significantly positive correlation between the expression of hTERTmRNA and mutant p53 protein in thyroid carcinoma, showing statistical significance(P＜0.05). Conclusion ① Overexpressed hTERTmRNA and mutant p53 protein may play an important role in the carcinogenesis and progression of thyroid carcinoma. ② Mutant p53 protein regulate and control the expression of hTERTmRNA. The expression rising of mutant p53 protein in thyroid carcinoma may activate the expression of hTERTmRNA, resulting in the occurrence of thyroid carcinoma. ③ Examination of expression of hTERTmRNA and mutant p53 protein may be helpful in judging the biological behavior and prognosis of thyroid carcinoma. It will perform an important directive function on the gene target therapy of thyroid carcinoma in clinical study.关键词
人端粒酶逆转录酶(hTERTmRNA)/突变型p53蛋白(mtp53)/甲状腺癌(TC)/原位杂交法(ISH)/免疫组织化学法(IHC)Key words
human telomerase reverse transcriptase/ mutant p53 protein/ thyroid carcinoma/ in situ hybridization/ immunohistochemistry分类
医药卫生引用本文复制引用
常青,陈春悠,胡耀杰..人端粒酶逆转录酶与p53蛋白在甲状腺癌组织中的表达、相关性及临床意义[J].实用临床医药杂志,2011,15(11):15-18,4.
