实用临床医药杂志2011，Vol.15Issue(11)：47-50,4.
还原型谷胱甘肽预防奥沙利铂所致神经毒性的临床观察
Clinical observation of the prevention against neurotoxicity related to Oxaliplatin with use of reduced glutathione
苑珩珩 1白玉贤 1孙秀威 1周建华 1韩宇 1魏孝礼1
作者信息
- 1. 哈尔滨医科大学附属第三医院,黑龙江,哈尔滨,150040
- 折叠
摘要
Abstract
Objective To explore the clinical application value of reduced Glutathione (GSH) to prevent and mitigate acute or chronic neurotoxicity with Oxaliplatin (OXL). Methods 106 patients of colon cancer adjuvant therapy with FOLFOX4 were randomly divided into two groups. In the treatment group, the patients were treated with GSH before and after using OXL; in the control group,the patients were treated without the use of GSH. The incidence and occurrence of acute and chronic neurotoxicity between the two groups were observed and analyzed to determine whether there was a difference in median progression - free survival (PFS) between the two groups. Results The total incidence of acute neurotoxicity in treatment group was 88.8％, while 90.3％ in the control group(P =0. 801 ). There was no significant difference between the two groups. The total incidence rate of chronic neurotoxicity in the treatment group was 88.9％, which was significantly lower than 100％ in the control group (P ＜ 0.05 ). With the increase of the cumulative dose of OXL, the neurologic toxicity rate was increased. After 46 months median follow - up with the treatment group and 46.5 months with the control group, the medial PFS was 51.8 and 49.2 months respectively. There was no significant difference. Conclusion Use of GSH before and after OXL can reduce the incidence and degree of chronic neurotoxicity, but has no effect on acute neurotoxicity. GSH does not affect the curative effect of OXL and the median PFS.关键词
结肠癌/奥沙利铂/神经毒性/还原型谷胱甘肽/预防Key words
Oxaliplatin/ neurotoxicity/ reduced glutathione/ prevention分类
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苑珩珩,白玉贤,孙秀威,周建华,韩宇,魏孝礼..还原型谷胱甘肽预防奥沙利铂所致神经毒性的临床观察[J].实用临床医药杂志,2011,15(11):47-50,4.
