实用临床医药杂志2011，Vol.15Issue(13)：77-78,83,3.
阿德福韦酯联合胸腺肽α1治疗慢性乙型肝炎的临床疗效分析
Analysis of clinical effect of Adefovir Dipivoxil combined with Thymosin α1 on chronic hepatitis B
胡日旺 1冀霞1
作者信息
- 1. 山西省大同市第四医院,肝病科,山西,大同,037008
- 折叠
摘要
Abstract
Objective To explore the clinical effect of Adefovir Dipivoxil combined with Thymosin α1 on chronic hepatitis B. Methods Sixty - four patients with chronic hepatitis B were randomly divided into combined treatment group( n = 32) and control group( n = 32). Patients in control group were only given Adefovir Dipivoxil 10mg/d for 72 weeks, while in combined treatment group, Thymosin was added α1 by the way of subcutaneous injection 1.6 rng twice per week during the first 24 weeks on the basis of control group. The levels of ALT, AST and TBIL were detected before and after treatment. HbeAg/HbeAb seroconversion and HBV-DNA negative conversion rates were observed every 24 weeks. Results No significant differences were found in liver function improvement and HBV- DNA negative conversion rates between two groups. However,the HbeAg/HbeAb seroconversion rates in combined treatment group were significantly higher than those in control group (P ＜0.05). Conclusion The clinical effect of Adefovir Dipivoxil combined with Thymosin α1 are significantly better than Adefovir Dipivoxil only on HbeAg/HbeAb seroconversion in the treatment of chronic hepatitis B.关键词
阿德福韦酯/胸腺肽α1/慢性乙型肝炎Key words
Adefovir Dipivoxil/ Thymosin α1/ chronic hepatitis B分类
医药卫生引用本文复制引用
胡日旺,冀霞..阿德福韦酯联合胸腺肽α1治疗慢性乙型肝炎的临床疗效分析[J].实用临床医药杂志,2011,15(13):77-78,83,3.
