国际医药卫生导报2011，Vol.17Issue(15)：1796-1798,3.DOI:10.3760/cma.j.issn.1007-1245.2011.15.002
四妙勇安汤不同配伍对其主要活性成分绿原酸吸收的影响
Effects of different formulations of Simiao yong'an decoction on absorption of the main active ingredient chlorogenic acid
摘要
Abstract
Objective To analyze the effects of different formulations of Simiao yong'an decoction on absorption of chlorogenic acid ( a main active ingredient in Simiao yong'an decoction ). Methods Various decoctions from the changes in formulation of Simiao yong'an decoction were administered via the duodenum in rats. The concentration of chlorogenic acid in the perfusate was detected with the LC-ESI-MS method 2 hous after perfusion of intestine-liver circulation. Results Different formulations of Simiao yong'an decoction had significant effects on absorption of chlorogenic acid. The absorption rate was ( 10.60 + 3.18 ) % in decoction with honeysuckle alone, ( 8.04 + 2.62 ) % in decoction with honeysuckle and angelica, ( 5.88 + 2.31 ) % in decoction with honeysuckle and figwort, ( 6.08 + 1.75 )% in decoction with honeysuckle and liquorice, and ( 6.38 + 2.16 )% in Simiao yong'an decoction. The absorption of chlorogenic acid was better in decoction with honeysuckle alone and decoction with honeysuckle and angelica than in decoction with honeysuckle and figwort,decoction with honeysuckle and liquorice, and Simiao yong'an decoction ( P ＜ 0.05 ). Conclusions Different formulations of Simiao yong'an decoction has a marked effect on absorption of chlorogenic acid.关键词
四妙勇安汤/绿原酸/吸收Key words
Simiao yong'an decoction/Chlorogenic acid/Absorption引用本文复制引用
王素军,阮金秀,莫李立,杨本坤,王桂香..四妙勇安汤不同配伍对其主要活性成分绿原酸吸收的影响[J].国际医药卫生导报,2011,17(15):1796-1798,3.基金项目
广东省自然科学基金(9152402301000007) （9152402301000007）
国家自然科学基金(81073141) （81073141）
