国际医药卫生导报2011，Vol.17Issue(16)：1955-1957,3.DOI:10.3760/cma.j.issn.1007-1245.2011.16.010
CCN2基因在结直肠癌中的表达及其临床意义的研究
The study of CCN2 gene expression in colorectal cancer and its clinic pathological significance
摘要
Abstract
Objective To research the CCN2 expression in colorectal carcinoma and its correlation with clinical pathological parameters. Methods Expression of CCN2 protein in several kinds of colorectal tissue was examined with immunohistochemistry. Results (1)CCN2 protein had high-expression in colorectal carcinoma and distant metastatic tissues in liver, the expressions were 75.00% and 70.00% respectively. And adenoma of colorectum,adjacent non-cancerous tissue, and mucosa tissue of normal rectum were low-expression of CCN2 protein; the expressions were 23.33%, 6.67%, and 0.00% respectively. The discrepancy had statistical significance (P＜ 0.001).(2)CCN2 protein expression had significant correlation with neoplasm phases, five-year survival rate, and lymph node metastasis (P ＜ 0.05). Conclusion CCN2 may be identified as an oncogene and play an important role on the occurrence and development of colorectal carcinoma. CCN2 may act as an effective indicator for diagnosing colorectal carcinoma and as a factor for assessing its prognosis.关键词
结直肠癌/免疫组织化学/CCN2Key words
Colorectal carcinoma/Immunohistochemistry/CCN2引用本文复制引用
王强,曹杰,梁立源,杨平..CCN2基因在结直肠癌中的表达及其临床意义的研究[J].国际医药卫生导报,2011,17(16):1955-1957,3.
