中国医学科学院学报2011，Vol.33Issue(3)：318-324,后插2-后插6,12.DOI:10.3881/j.issn.1000-503X.2011.03.021
灵芝制剂治疗猴获得性免疫缺陷综合征的疗效观察
Effectiveness of Gonderma Lucidum Preparation in Treating Simian Acquired Immune Deficiency Syndrome
卢耀增 1吴小闲 1陈颂 2袁菊 2赖春辉 2鲍琳琳 1孙丽华 1卢葳2
作者信息
- 1. 中国医学科学院,北京协和医学院医学实验动物研究所卫生部人类疾病比较医学重点实验室国家中医药管理局人类疾病动物模型三级实验室,北京,100021
- 2. 法国发展研究院UMRl45研究所中国分部,北京,100730
- 折叠
摘要
Abstract
Objective To explore the effectiveness of the traditional Chinese herbal medicine Lingzhi (Gonoderma lucidum) preparation in treating simian acquired immune deficiency syndrome (SAIDS).Methods Five female adult Chinese rhesus monkeys were inoculated rectally with SIVmac239, and were all diagnosed as SAIDS by laboratory and clinical examinations 17 months later.Of these 5 monkeys, 3 (#393, #374,and #381; treatment group) were orally administered with Gonoderma lucidum (2 spores powder capsules plus 2 spores oil capsules on a daily basis) , and the remaining other two monkeys ( #348 and #361 ) served as control and did not receive treatment.Results Animal #393 ( treatment group), #361 ( control group) and #348 (control group) died of SAIDS (opportunity infection) 3.5 months, 6 months, and 11 months later, respectively.Two animals (#374 and #381 ) survived.The necropsy revealed depletion and/or exhaustions of their lymphoid tissue.In the monkey #374, the peripheral CD4 + T lymphocyte increased by 30％ in the 6th month compared with the baseline level and then fluctuated.The plasma viral load gradually fell and reached about 1 log10 in the treatment group, but remained stable in the control group.As shown by pathological examinations,the lymph node and spleen of monkeys #374 ( treatment group) and #381 ( treatment group) showed rehabilitation and reconstruction in the lymphatic tissue, thymus, nerve tissue of gyrus hippocampi, pituitary gland, pineal body, thyroid gland, adrenal gland, and ovary.In the control group, however, animals experienced depletion of lymph nodes, atrophy of spleen, disappearance of thymus, and other disorders in endocrine organs.Conclusion Gonderma bucidum preparation may have certain protective effect on the immune system, nervous system, and endocrine system of monkeys with SAIDS.关键词
猴获得性免疫缺陷综合征/灵芝/淋巴组织耗竭与重建/胸腺再生/神经细胞保护与增生/内分泌恢复Key words
simian acquired immune deficiency syndrome/ gonderma lucidum/ lymphoid tissue depletion and reconstruction/regeneration of thymus/ neuron protection and hyperplasia/ endocrine rehabilitation分类
医药卫生引用本文复制引用
卢耀增,吴小闲,陈颂,袁菊,赖春辉,鲍琳琳,孙丽华,卢葳..灵芝制剂治疗猴获得性免疫缺陷综合征的疗效观察[J].中国医学科学院学报,2011,33(3):318-324,后插2-后插6,12.
