中医学报2011，Vol.26Issue(6)：717-720,4.
桂枝人参汤加味对2型糖尿病胰岛素抵抗的干预研究
Effect of Modified Guizhi Renshen Decoction on the Symptoms and Serum Lipids of Type 2 Diabetic Patients with Insulin Resistance
摘要
Abstract
Objective:To observe the effect of modified Guizhi Renshen Decoction on the symptoms and serum lipidis of type 2 diabetic patients with insulin resistance. Methods: 60 cases divided into the treatment group and the control group with 30 cases for each group according to the visiting sequence. The treatment group was given water extract of modified Guizhi Renshen Decoction while the control group was administered 4 mg of Rosiglitazone tablets, once a day with two months as a course of treatment. All the patients received two courses of treatment. Changes of the serum lipids were observed; Body Mass Index (BMI) and waist - hip ratio (WHR) of the patients were compared; the treatment efficacies of both groups were compared according to the symptom scores. Results: BMI and WHR in both groups decreased and the differences were remarkable compared with those before treatment (P ＜0.01 ). TC, TG, LDL,VLDL in both groups decreased greatly while HDL increased significantly with extremely remarkable difference compared with those before the treatment (P＜0.01 ). The effective rate of the treatment group was 90.0％, which was superior to that of the control group with a rate of 71.0％ (P＜0.05). Conclusion: Modified Guizhi Renshen Decoction can regulate the lipid metabolism of IR patients,alleviate obesity and remarkably improve the clinical symptoms of IR patients with a better therapeutic efficacy than the western medicine Rosiglitazone.关键词
2型糖尿病/桂枝人参汤/健脾法/胰岛素抵抗Key words
type 2 diabetes/ Guizhi Renshen Decoction/ treatment method of activating the spleen/ insulin resistance分类
医药卫生引用本文复制引用
邱昌龙,杨晓溪,赵舒,喇孝瑾,王志文,王兴华..桂枝人参汤加味对2型糖尿病胰岛素抵抗的干预研究[J].中医学报,2011,26(6):717-720,4.基金项目
国家科技部国际合作项目(编号:2008DFA31050) （编号:2008DFA31050）
