武警医学2011，Vol.22Issue(6)：510-512,3.
MMP-2C-735T基因多态性与高血压伴颈动脉粥样硬化的关系
Single nucleotide polymorphism of matrix metalloproteinase-2-735C/T is associated with essential hypertension accompanied by carotid atherosclerosis
马岩萍 1徐新娟 2李孝华1
作者信息
- 1. 830091,乌鲁木齐,武警新疆总队医院高血压科
- 2. 830054,乌鲁木齐,新疆医科大学第一附属医院高血压科
- 折叠
摘要
Abstract
Objective To investigate the relationship between the single nucleotide polymorphism of matrix metalloproteinase - 2 (MMP-2) - 735C/T and essential hypertension accompanied by carotid atherosclerosis in Chinese Han population.Methods Genotypes were detected by polymerase chain reactions followed by restriction analyses with specific endonucleases and their frequencies were determined.Results Individuals with TT genotype were 2.244 times as likely to suffer from essential hypertension with carotid atherosclerosis as those ones with CC and CT genotypes.Conclusion The single nucleotide polymorphism of matrix metalloproteinase -2(MMP -2) - 735C/T is probably associated with carotid atherosclerosis in patients with essential hypertension in Chinese Han population.关键词
基质金属蛋白酶-2/基因多态性/高血压/颈动脉粥样硬化Key words
MMP - 2 gene/ polymorphism/ essential hypertension/ atherosclerosis分类
医药卫生引用本文复制引用
马岩萍,徐新娟,李孝华..MMP-2C-735T基因多态性与高血压伴颈动脉粥样硬化的关系[J].武警医学,2011,22(6):510-512,3.
