武警医学2011，Vol.22Issue(6)：513-516,4.
东北红豆杉中19种单体化合物对宫颈癌HeLa细胞增殖的影响
Effects of taxnae and related analogues from taxus cuspidata on proliferation of HeLa cervical cancer cell line
摘要
Abstract
Objective To study the effect of 19 kinds of taxnae and related analogues from T.cuspidata on the proliferation of HeLa cervical cancer cells.Methods The effect of 19 kinds of taxnae and related analogues from T.cuspidata on the proliferation of HeLa cervical cancer cells were evaluated by MTT assay.Results After treatment with taxnae and related analogues ( 10-4 mol/L) for 48h, Compound 5,7, and 16 inhibited the proliferation of HeLa cells significantly ( P ＜ 0.01 ).The survival rate of HeLa cells was 26.93％ , 20.79％ and 32.82％ , respectively.In the 10-6 ～ 10-4 mol / L concentration range, the Compound 3 and 14 showed a definite dose - dependent relationship.Conclusion The five types of taxanes can inhibit the proliferation of cervical cancer HeLa cells to different extents.关键词
东北红豆杉/紫杉烷类化合物/宫颈癌HeLa细胞/MTT法Key words
Taxus cuspidata/Taxnae/HeLa cervical cancer cells/MTT assay分类
医药卫生引用本文复制引用
许立,李霞,张茶,孙剑,董辉,董玫,史清文..东北红豆杉中19种单体化合物对宫颈癌HeLa细胞增殖的影响[J].武警医学,2011,22(6):513-516,4.基金项目
科技部863科研基金(2003AA2Z3527) （2003AA2Z3527）
