中国肿瘤生物治疗杂志2011，Vol.18Issue(3)：320-323,4.DOI:10.3872/j.issn.1007-385X.2011.03.016
胃癌组织中miR-29的表达及其临床意义
Expression of miR-29 in gastric cancer and its clinical significance
摘要
Abstract
Objective: To explore the expression of miR-29 in gastric cancer and its relationship with clinic pathological features and prognosis of gastric cancer. Methods: Totally 113 gastric cancer samples were obtained from patients who received operation during 2005 to 2010 in the No. 324 Hospital of PLA. The expression of miR-29 in gastric cancer and paracancerous tissues was detected by real-time PCR, and its relationship with clinic pathological features of gastric cancer was analyzed. Results: The expression of miR-29 in gastric cancer tissues was significantly lower than that in paracancerous tissues (2.62 ± 1.17 vs 3.14 ± 1.70, P =0. 006). The rate of low miR-29 expression in patients with lymph node metastases was significantly higher than that without lymph node metastases (58.9％ vs 32.5 ％ , P = 0. 007 ). The median survival rate in low miR-29 expression cases was significantly lower than that in high miR-29 expression cases ( 33.0 vs 44.0 month, P = 0. 013 ). Conclusion: miR-29 is lowly expressed in gastric cancer tissues, and it might be used for prediction of prognosis and as for targeted treatment of gastric cancer.关键词
胃癌/microRNA/miR-29/转移/预后Key words
gastric cancer/ microRNA/ miR-29/ metastasis/ prognosis分类
医药卫生引用本文复制引用
陈陵,王宗华,李学成,邹利全,范亚川,刘志鹏,熊晓峰..胃癌组织中miR-29的表达及其临床意义[J].中国肿瘤生物治疗杂志,2011,18(3):320-323,4.基金项目
重庆市自然科学基金资助项目(No.2008BB5274,No.2009BB5314,No.2010BB5158). （No.2008BB5274,No.2009BB5314,No.2010BB5158）
