摘要
Abstract
Objective To evaluate the diagnostic value of multiple tumor markers protein biochip (C-12) for patients with cholangiocarcinoma. Methods The serum levels of 12 tumor markers (TMs), including CA199, NSE, CEA, CA242, Ferritin, β-HCG, AFP, f-PSA, PSA, CA125, CA153 and HGH, were measured in 26 cholangio carcinoma patients, 52 benign disease patients of digestive system and 65 controls. The most relevant TM and the combinations of TMs to the improvement of diagnosis were determined. Results The positive rates of CA199, CEA, CA242, Ferritin, AFP, CA125 and CA153 in the cholangiocarcinoma patients had significantly higher than those of the benign disease patients and normal controls (P ＜0. 01 ). The serum levels of CA199, NSE, CA242, Ferritin, β-HCG, AFP, CA125, HGH and CA153 in the cholangiocarcinoma patients had significantly higher than those of the benign disease patients and normal controls ( P ＜ 0. 05 ～ 0. 01 ). Among all the 12 TMs, the single best TM was CA199 and showed the sensitivity, specificity and validity of 69. 2％, 96. 9％ and 89. 0％ for the cholangiocarcinoma, respectively. The best combination of 3 TMs (CA199 + CA125 + CEA) had not statistically significant difference as comparied with C-12 and yielded a sensitivity of 91.7％, a specificity of 87. 5％ and a validity of 89. 6％. Conclusion The multiple tumor markers protein biochip has a relatively high value in the diagnosis of cholangiocarcinoma.关键词
肿瘤标志物/蛋白质阵列分析/诊断/胆管癌Key words
tumor markers/ protein array analysis/ diagnosis/ cholangiocarcinoma分类
医药卫生
