摘要
Abstract
Objective To investigate the impact of anti-anxiety/antidepressant treatment on the blood glucose profile in patients with type 2 diabetes. Methods Sixty type 2 diabetes patients with a tendency of anxiety or depression diagnosed according to the Zung self-rating depression scale (SDS) and Zung self-rating anxiety scale (SAS)were randomly assigned to received either anti-diabetic treatment solely as the control group, or in combination with anti-anxiety or antidepressant therapy as the intervention group. After 12-weak treatment, the changes in the index of anxiety (SDS)/depression (SAS), fasting blood glucose and HbA1C were compared between the two groups.Results Compared with that before treatment, the SDS, SAS, FBG, and HbA1C were significantly decreased in both intervention group and control group, In intervention group, FBG decreased from 9. 14 ± 1.58 mmol/L to 6. 90 ±0. 73 mmol/L, and HbAlC decreased form 9.88％ ± 1.96％ to 7.60％ ± 1.00％ respectively after treatment (P ＜0.05). In the control group, the corresponding parameters was 9. 09 ± 1.69 mmoL/L, and 9. 68％ ± 0. 19％ respectively before treatment, decreased to 7. 60 ±0. 81 mmol/L,and 8. 09％ ±0. 83％ respectively after treatment(P ＜0. 05). The reduction in FBG and HbA1C was significantly greater in intervention group as compared to control group. Conclusion In type 2 diabetes patients with anxiety/depression tendency, anti-anxiety/antidepressant treatment can improve the blood glucose profile.关键词
2型糖尿病/焦虑/抑郁Key words
type 2 diabetes/ anxiety/ depression分类
医药卫生
