中国当代儿科杂志2011，Vol.13Issue(7)：551-553,3.
支气管哮喘儿童血清25-(OH)D3和总免疫球蛋白E的变化
Serum levels of 25-(OH)D3 and total IgE in children with asthma
马秀丽 1甄艳芬1
作者信息
- 1. 中国人民解放军第253医院儿科,内蒙古,呼和浩特,010051
- 折叠
摘要
Abstract
Objective To study the changes and clinical significance of serum levels of 25-(OH)D3 and total IgE in children with asthma. Methods Thirty children with asthma, 40 children with asthmatic bronchitis, and 40 healthy children were enrolled. Double-antibody radioimmunoassay was used to detect the levels of serum 25-( OH ) D3 and total IgE. Results Serum 25-(OH) D3 levels( 18 ± 3 ng/mL)decreased significantly in the asthmatic group compared with those in the asthmatic bronchitis group (43 ±3 ng/mL) and the control group (43 ±3 ng/mL) (P ＜0.01). In contrast, serum total IgE levels ( 192 ± 16 IU/mL) increased significantly in the asthmatic group compared with those in the asthmatic bronchitis group ( 123 ± 14 IU/mL) and the control group ( 118 ± 15 IU/mL) (P ＜0.01 ). Serum 25-(OH) D3 levels were negatively correlated with serum total IgE levels in asthmatic children (r = -0.783, P ＜0.01 ). There were no correlation between serum 25-( OH ) D3 levels and serum total IgE level in the asthmatic bronchitis and the control groups.Conclusions 25-(OH) D3 may play an important role in the pathogenesis of asthma. The increased serum 25-(OH) D3level may inhibit total IgE expression, suggesting that increasing serum 25-(OH) D3 level might be a new option for the prevention and treatment of asthma.关键词
支气管哮喘/喘息性支气管炎/25-羟维生素D3/总免疫球蛋白E/儿童Key words
Asthma/ Asthmatic bronchitis/ 25-(OH)D3/ Total IgE/ Child分类
医药卫生引用本文复制引用
马秀丽,甄艳芬..支气管哮喘儿童血清25-(OH)D3和总免疫球蛋白E的变化[J].中国当代儿科杂志,2011,13(7):551-553,3.
