昆明医学院学报2011，Vol.32Issue(6)：56-58,67,4.
谷胱甘肽硫转移酶基因GSTM1与宣威肺癌易感性关系的研究
The Relationship between Glutathione S-transferase M1 and Susceptibility to Xuanwei' s Lung Cancer
摘要
Abstract
Objective To investigate the relationship between GSTMlgenetic polymorphism and lung cancer susceptibility in Xuanwei, China.Method In a case-control study, PCR and RFLP was used to identify the genotypes of GSTM1 in 50 lung cancer cases and 50 controls.Results GSTM1 polymorphism showed frequency distribution differences, OR = 2.71 (1.20 ～ 6.11 ).There was a significant difference between the case group and the control group (P ＜ 0.05 ).Using bituminous coal was strongly associated with the risk of lung cancer (OR =3.78, P＜ 0.01 ).People using bituminous coal with GSTM1 (-/-) genotype had an odds ratio of lung cancer compared with people not using bituminous coal with GSTM1 (+/+) genotype (OR = 9.23 (2.24 ～ 38.29, and there was a significant difference (P ＜0.01 ).Conclusions GSTM1 null genotype increases the risk of lung cancer, Persons using bituminous coal with GSTM1 null genotype have higher risk of lung cancer.关键词
GSTM1/基因多态性/肺肿瘤/易感性Key words
Glutathione S-transferase M1/ Polymorphism/ Lung neoplasm/ Susceptibility分类
医药卫生引用本文复制引用
张剑青,龙翔宇,熊国盛,方利洲,赵芝焕,戴路明..谷胱甘肽硫转移酶基因GSTM1与宣威肺癌易感性关系的研究[J].昆明医学院学报,2011,32(6):56-58,67,4.基金项目
云南省教育厅科学研究基金资助项目(06Y211C) （06Y211C）
