临床肝胆病杂志2011，Vol.27Issue(6)：591-594,4.
原发性硬化性胆管炎的诊断和治疗
Diagnosis and treatment of primary sclerosing cholangitis
舒慧君 1朱峰1
作者信息
- 1. 中国医学科学院北京协和医院消化内科,北京100730
- 折叠
摘要
Abstract
Primary sclerosing cholangitis (PSC) is a chronic, cholestatic liver disease characterized by inflammation and fibrosis of both intra- and extra-hepatic bile ducts, leading to the formation of multifocal bile duct strictures and eventually cirrhosis and end-stage liver disease.Genetic and immunologic factors appear to play key roles in disease susceptibility and progression.Patients with histological,biological and clinical features of PSC but with normal cholangiogram are diagnosed as small duct PSC.PSC is strongly associated with inflammatory bowel disease (IBD) and cholangiocarcinoma.The reported frequency of IBD and cholangiocarcinoma in patients with PSC is 60％-80％ and 20％ respectively.Except for liver transplantation, no specific therapy has been proved effective for PSC.关键词
胆管炎/硬化性Key words
cholangitis/ sclerosing分类
医药卫生引用本文复制引用
舒慧君,朱峰..原发性硬化性胆管炎的诊断和治疗[J].临床肝胆病杂志,2011,27(6):591-594,4.
