摘要
Abstract
Objective To explore the clinical significance of C-terminal portion of provasopressin (Copeptin), cTnI and Hs-CRP in patients with acute coronary syndrome (ACS).Methods This study consisted of 194 patients who were hospitalized with chest pain.According to coronary angiography (CAG), they were classified into four groups as: CAG normal, unstable angina pectoris (UAP), non-ST elevation myocardial infarction (NSTEMI) and ST elevation myocardial infarction (STEM1).Plasma copeptin, cTnI and Hs-CRP were measured on admission.Results Plasma levels of copeptin, cTnI and Hs-CRP in patients of groups UAP, NSTEMI and STEMI were significantly higher than that in CAG normal group (H=42.57-141.35, P＜0.05).The levels of copeptin, cTnI and Hs-CRP in patients of groups NSTEMI and STEMI were higher than that in UAP group (H=9.72-107.45,P＜0.05).The patients with left main coronary stenosis had a higher level of copeptin, cTnI and Hs-CRP than those with a single-, double-or triple-branch coronary stenosis (H=7.26-35.72,P＜0.05).Conclusion Plasma level of copeptin, cTnI and Hs-CRP is elevated in ACS patients.Copeptin and cTnI, to some extent, may reflect the severity of coronary artery lesion,which is of a clinical value on risk stratification, therapeutic decision-making, and prognostic prediction for patients with ACS.关键词
急性冠状动脉综合征/和肽素/肌钙蛋白I/C反应蛋白质Key words
acute coronary syndrome/ copeptin/ troponin Ⅰ/ C-reactive protein分类
医药卫生
