青岛大学医学院学报2011，Vol.47Issue(5)：444-446,449,4.
川崎病并发巨噬细胞活化综合征(附3例报告并文献分析)
KAWASAKI DISEASE FOLLOWED BY MACROPHAGE ACTIVATION SYNDROME: REPORT OF THREE CASES AND REVIEW OF LITERATURES
张艳艳 1卢彦敏 2李自普1
作者信息
- 1. 青岛大学医学院附属医院儿科,山东青岛266003
- 2. 青岛市经济技术开发区第一人民医院
- 折叠
摘要
Abstract
Objective To understand clinical characteristics of Kawasaki disease followed by macrophage activation syndrome (MAS) in children. Methods Clinical features of three cases of Kawasaki disease associated with MAS treated in our hospital, from November 2009 to April 2010, were summarized, and 17 cases reported in literature were analyzed as well. Results There were 14 boys and six girls in this group, age ranged (mean) 1- 11(5. 35±3. 66) years old. The main clinical manifestations were: persistent fever, hepatosplenomegaly, hypocytosia, coagulation disorders, hepatic enzymes increased, hypertriglyceridemia, hypofibrinogenemia, serum ferritin increased; hemophagocytes found in bone marrow. Co-therapy with hormonal, highdose gamma globulin, and immunosuppressive agents was effective for this disease. Of the 20 cases reviewed, one gave up treatment, the rest 19 children survived. Conclusion MAS is a serious complication of Kawaski disease, an early reasonable therapy may improve the prognosis of children with this condition.关键词
黏膜皮肤淋巴结综合征/风湿性疾病/巨噬细胞活化综合征/儿童Key words
mucocutaneous lymph node syndrome/ rheumatic diseases/ macrophage activation syndrome/ child分类
临床医学引用本文复制引用
张艳艳,卢彦敏,李自普..川崎病并发巨噬细胞活化综合征(附3例报告并文献分析)[J].青岛大学医学院学报,2011,47(5):444-446,449,4.
