天然产物研究与开发2011，Vol.23Issue(3)：410-414,5.
海洋链霉菌S007次生代谢产物的分离鉴定
Isolation and Identification of Metabolites Produced by Marine Streptomyces sp.S007
摘要
Abstract
Nine metabolites thymine ( 1 ), pyrrole-2-carboxylic acid ( 2 ), kalamycin (3), 3 -indole propionic acid (4),indol-3-carboxylic acid (5), N-acetyl-tyramine (6), 2'-deoxythymidine (7), N-β-acetyltryptamine ( 8 ), and triethylamine hycdrochloride (9) were isolated by column and preparative thin layer chromatography from the extract of fermented broth of Streptomycete sp.S007.Their structures were established by NMR and MS data.Among of them,9 was firstly obtained from Streptomycete;The brine shrimp bioassay showed the morality rates of kalamycin to brine shrimp are 86.5％ at a concentration of 40 μg/mL,indicating kalamycin possessed significant toxicity on brine shrimp.关键词
海洋链霉菌S007/次生代谢产物/海虾/细胞毒性/卡拉霉素Key words
marine Streptomyces sp.S007 /secondary metabolite/ brine shrimp/ cytotoxicity/ kalamycin分类
医药卫生引用本文复制引用
张宏宇,秦梅,李富超,LAATSCH Hartmut,王宏鹏,秦松..海洋链霉菌S007次生代谢产物的分离鉴定[J].天然产物研究与开发,2011,23(3):410-414,5.基金项目
This work was supported by the International Innova tion Partnership Program:Typical Environmental Process and Effects on Resources in Coastal Zone Area,the research fund of Qufu Normal University (X J0718 ),the National Natural Science Foundation of China (31000037),and the Knowledge Innovation Program of the Chinese Academy of Sciences(KSCX2-YW-G-073,KZCX2-YW-216,KZCX2YW-209) （X J0718 ）
