现代妇产科进展2011，Vol.20Issue(6)：428-431,4.
妇科恶性肿瘤年轻患者化疗后骨密度23例临床分析
A clinical analysis of bone mineral density after chemotherapy in 23 young patients with gynecological malignancies
摘要
Abstract
Objective: To invesitgate the charactristics of ehange of the hone mineral density (BMD) after chemotherapy in young gynecological malignancies for proiding a basis for the clinical prevention of osteoporosis after chemotherapy. Methods : 23 young patients ( ≤40years old) with gynecological malignancies who accepted chemotherapy were divided into 2 groups according to age ( ≤26 years old and ＞26 years old). The BMD was detected on the lumbar spine, proximal femur and forearm respectively, and their serum hormone levels and blood magnesium, calcium and phosphate ions levels were determined at the same time. Results : ( 1) For all 23 patients, the incidence of BMD reduction was 43. 5％ . In the group ≤26 years old,BMD decreased in 6 cases ( 66. 7％ , 6/9) and 4 cases in the group ＞26 years old (28. 57％ ,4/14). Lumbar spine L1 - L4 BMD in the group ≤ 26 years old was significantly lower than that of the group＞26 years old ( P＜O. 05 ) . (2) The difference of the incidence of BMD reduction was not significant between the patients accepted chemotherapy alone and combined with radiotherapy. ( 3) The LH and FSH levels were significantly different between the two groups( P＜0. 05 ) ,while the other hormones and electrolyte levels were not signiricantly different. Conclusion: The young patients with gynecological malignancies prone to have a decrease in BMD during chemotherapy, even have the possibility of osteoporosis. The research in prevention and treatment to improve the quality of life for the patients is very important.关键词
年轻女性/妇科恶性肿瘤/骨密度/化疗Key words
Young females/ Gynecological malignant tumor/ Bone mineral density/Chemotherapy分类
医药卫生引用本文复制引用
徐启英,孙秀丽,李小平,刘杰,苗懿德,王建六,魏丽惠..妇科恶性肿瘤年轻患者化疗后骨密度23例临床分析[J].现代妇产科进展,2011,20(6):428-431,4.基金项目
北京大学人民医院研究与发展基金资助(No:RD12008-02) （No:RD12008-02）
