现代妇产科进展2011，Vol.20Issue(6)：470-472,3.
超长方案在卵巢储备良好前次IVF/ICSI-ET失败患者中的应用分析
Clinical outcomes of prolonged gonadotropin-releasing hormone agonist(GnRH-a) therapy used in patients with good ovarian reserves and previous in vitro fertilization or intracytoplasmic sperm injection embryo transfer(IVF/ICSI-ET) failure cycle
聂玲 1伍琼芳 2张寅 1陈晶晶2
作者信息
- 1. 南昌大学医学院,南昌330006
- 2. 江西省妇幼保健院生殖中心
- 折叠
摘要
Abstract
Objective : To evaluate the clinical outcomes of prolonged gonadotropm-releasing hormone agonist therapy( GnRH-a) used in patients with good ovanan reserves and previous in vitro fertilization or intracytoplasmic sperm injection embryo transfer( IVF/ICSI-ET) failure cycle. Methods : Retrospective analyze a total of 246 patients with previous IVF-ET failure cycle and good ovarian reserve who underwent the secondary IVF-ET cycles. Patients were divided into two groups : the study group included 52 patients applied with prolonged protocol;the control group included 194 patients applied with long protocol. Results : The numher of oocytes retrieved and the duration of gonadotropin ( Gn) were significantly higher in the study group(P＜0. 01). But there were no significant differences in the dose of Gn,total numher of good quality embryos, mean endometrium thickness on transfer day ,mean serum P level on human chorionic gonadotrophin ( HCG) day and severe ovarian hyperstimulation syndrome ( OHSS) rate between the two groups (P＞ 0. 05). The positive HCG rate and clinical pregnancy rate( CPR) increased obviously in the study group, respectively ( 79. l％ vs 61. 1％ , P =0. 03 ;69. 8％ vs 54. 9％ , P=O. 048 ) . And there was an mcreasing tendency in implantation rate ( 39. 5％ vs 31. 5％ , P = 0. 18 ) . Conclusion : Using prolonged gonadotropin-releasing hormone agonist therapy in patients with good ovarian reserves and previous IVF-ET failure cycle may make the endometrium receptivity better than using the long protocol, and improve obviously the clinical pregnancy outcomes. So the prolonged protocol is recommendable.关键词
超长方案/体外受精-胚胎移植/促性腺激素释放激素激动剂/子宫内膜容受性/胚胎种植率/临床妊娠率Key words
Prolonged protocol/ln vitro fertilization-embryo transfer/ Conadotropin-releasing hormone agonist / Endometrium receptivity / Embryo implantaon rate / Clinical pregnancy rate分类
医药卫生引用本文复制引用
聂玲,伍琼芳,张寅,陈晶晶..超长方案在卵巢储备良好前次IVF/ICSI-ET失败患者中的应用分析[J].现代妇产科进展,2011,20(6):470-472,3.
