四川医学2011，Vol.32Issue(6)：793-796,4.
多体素磁共振氢质子波谱在脑胶质瘤诊断及分级中的初步应用研究
Evaluation of cerebral glioma grade by using multivoxel 3D proton MR spectroscopy
摘要
Abstract
Objective To determine whether metabolite ratios in multivoxel 3D proton MR spectroscopy(1H-MRS) is different between low-grade and high-grade gliomas and may be useful for diagnosis and glioma grading. Methods MR scan and 3D 1 H-MRS studies of 51 patients with histologically proven (16 low-grade ,4 Ⅱ -Ⅲ-grade and 31 hight-grade glimas) were retrospectively reviewde. Metabolite Cho,Cr,NAA and metabolite ratios Cho/NAA Cho/Cr,NAA/Cr were measured. The metabolite ratios ( Cho/NAA, Cho/Cr, NAA/Cr ) of low and high-grade gliomas were statistically analyzed. Results The Cho within voxel increased means the tumor proliferation activity. The NAA within voxel reduced means neuronal damaged. The metabolite ratios (Cho/NAA,Cho/Cr,NAA/Cr ) of low and high-grade gliomas was significant difference (P ＜ 0. 05 ). Conclusion Metabolite ratios of low-grade gliomas were significantly different from high-grade gliomas. 1H-MRS combined with morphological changes could be useful in gliomas diagnosis and differential diagnosis and grading. 1H-MRS metabolite changes were sensitive, and is closely related to contained tissue within voxel. Analysis of metabolites changes should be combined with the corresponding region of morphological changes.关键词
肿瘤/神经上皮/磁共振波谱Key words
neoplasms/ neuroepithelial/ magnetic resonance spectroscopy分类
医药卫生引用本文复制引用
任静,周鹏,左佳明,刘锦,王闽,杨宇洁,陈锦秀,许国辉..多体素磁共振氢质子波谱在脑胶质瘤诊断及分级中的初步应用研究[J].四川医学,2011,32(6):793-796,4.基金项目
四川省卫生厅课题(编号:070025) （编号:070025）
