摘要
Abstract
Objective To study the dose of liquor on vascular endothelial function, blood lipid and blood glucose.Methods 60 healthy male SD rats with normal levels, were randomly divided into high dose group ( A group), middle dose group ( B group), low dose group ( C group) and control group ( D group). Established animal model of ethanol feeding for 8 weeks , the concentrations of plasma nitric oxide ( NO), angiotensin II ( Ang I ), total cholesterol (TC), triglyceride (TG), high density lipoprotein ( HDL-C ), low density lipoprotein (LDL-C) and blood glucose levels and nitric oxide synthase (total NOS, endothelial eNOS, inducible iNOS) activity were detected. Results In A, B and D group,NO, NOS, eNOS, Ang Ⅱ, TC, glucose significantly changed (P＜0.05). In C, D group,there were no significant changes in these indicators (P ＞ 0.05 ). In A, B, C group and D group, HDL-C changed significantly (P ＜ 0.05). In A group and B, C, Dgroup, iNOS significantly changed (P＜0.05). Conclusions Different doses of alcohol could affect on vascular endothelial function. NOS (including eNOS and iNOS) activity might play an important role.关键词
乙醇/大鼠/内皮,血管/血脂/血糖Key words
alcohol/ rat/ endothelial, vascular/ blood lipid/ blood glucose分类
医药卫生
