山东医药2011，Vol.51Issue(27)：10-12,3.
脑胶质瘤组织中MCMS、Ki-67的表达及临床意义
Expression and significance of MCM5 and Ki-67 in human glioma
摘要
Abstract
Objective To explore the significance of MCM5 and Ki-67 in the development and progression of glioma.Methods Forty-four resected gliomas specimens ( tumor group) and 6 normal brain tissues ( normal group) were selected,and the expression of MCM5 and Ki-67 were assessed by immunohistochemistry staining [ the results were expressed as labeling index (LI) ]. The correlation between the two parameters and clinicopathological features in tumor group were ahalyzed using spearman rank correlation analysis. Results The LI for MCM5 in tumor group and normal group were 12.96 ±8.49 and 0 respectively (P ＜0.05 ); the LI for Ki-67 in tumor group and normal group was 10.09 ± 7.07 and 0 respectively (P ＜0.05). The positive expression of MCM5 and Ki-67 was closely related to glioma differentiation. MCM5 expression was significantly higher than Ki-67 expression in tumors with different grades, and the two indexes were positively associated with each other. Conclusions The high expression of MCM5 and Ki-67 play an important role in incidence and development of glioma; the MCM5 is more sensitive in reflecting the vegetative state of tumor cell.关键词
脑胶质瘤/微小染色体维持蛋白5/细胞增殖相关核蛋白/免疫组织化学Key words
glioma/ minichromosome maintenance proteins 5/ cell proliferation antigen/ immunohistochemistry分类
医药卫生引用本文复制引用
刘馨莲,李淑蓉,殷舞,孙静..脑胶质瘤组织中MCMS、Ki-67的表达及临床意义[J].山东医药,2011,51(27):10-12,3.基金项目
成都医学院科研课题项目(CYZ07-003). （CYZ07-003）
