山东医药2011，Vol.51Issue(27)：25-26,2.
甲状腺乳头状癌患者血液p53基因表达及与淋巴结转移、临床分期的关系
Expression of serum p53 gene and its correlation with lymphatic metastasis and clinical stages in patients with thyroid papillary carcinoma
摘要
Abstract
Objeetive To explore the role of p53 gene mutation in the occurrence and development of thyroid papillary carcinoma(PTC). Methods One hundred and eighteen patients with PT( PTC group), 38 cases of thyroid carcinoma with lymphatic metastasis(metastasis group) and 122 healthy controls( control group) were enrolled in, the 5-8 exons of p53 gene of the three groups was monitored using polymerase chain reaction-single strand conformation polymorphism( PCR-SSCP). Results p53 mutation rates in PTC group and metastasis group were both higher significantly than that in control group, especially in the metastasis group, those of patient in Ⅲ-Ⅳ stage were significantly higher than with that in Ⅰ-Ⅱ( all P ＜ 0.05). Conclusions p53 gene mutation may improve the occurrence and metastasis of PTC; this can provide hasis for the diagnosis and treatment, decision of prognosis of PTC.关键词
甲状腺乳头状癌/p53基因/聚合酶链式反应--单链构象多态Key words
thyroid papillary carcinoma/ p53 gene/ polymerase chain reaction-single strand conformation polymorphism分类
医药卫生引用本文复制引用
尹凤媛,焦淑贤,迟晓云..甲状腺乳头状癌患者血液p53基因表达及与淋巴结转移、临床分期的关系[J].山东医药,2011,51(27):25-26,2.基金项目
青岛市市南区科技发展计划资助项目(2009-5-21-GG). （2009-5-21-GG）
