实验动物与比较医学2011，Vol.31Issue(4)：248-251,4.DOI:10.3969/j.issn.1674-5817.2011.04.004
内毒素致绵羊急性呼吸窘迫综合征多脏器的病理学改变
Pathological Changes of Multi-organ in Acute Respiratory Distress Syndrome Induced by Lipopolysaccharide in Sheep
摘要
Abstract
Objective To observe the pathological changes of multi-organ in acute respiratory distress syndrome(ARDS). Methods The sheep model of ARDS was established by infusing low dose lipopolysaccharide (LPS) intravenously. The sheep were sacrifised after 72 hours, the organs were collected and fixed by 10％ formalin. Routine olefin cut sheets were made and stained by hematine-eosin.Then their pathology changes were observed under light microscope. Results Each organ has pathology change in different degree. The most severe organs of pathology change were lung and kidney, liver and spleen were secondary, but heart was not obvious. Moreover the key features of pathology change in organ were stagnant blood, degeneration and necrosis. Conclusion The multi-organ had pathology changes in different degree in ARDS by LPS inducement and lung was the first target organ that was the easiest impaired.关键词
急性呼吸窘迫综合征(ARDS)/绵羊/内毒素(LPS)/病理学改变Key words
Acute Respiratory Distress Syndrome(ARDS)/ Sheep/ Lipopolysaccharide (LPS)/Pathological change分类
生物科学引用本文复制引用
牛廷献,罗晓红,万东君,史智勇,王红义,陆璐..内毒素致绵羊急性呼吸窘迫综合征多脏器的病理学改变[J].实验动物与比较医学,2011,31(4):248-251,4.基金项目
甘肃省自然科学基金(No.1010RJZA052) （No.1010RJZA052）
