实验动物与比较医学2011，Vol.31Issue(4)：255-258,4.DOI:10.3969/j.issn.1674-5817.2011.04.006
量子点的急性毒性及动力学初步观察
Observations on Distribution of Quantum Dots and Acute Toxicity in Rats
摘要
Abstract
Objective To study the acute toxicity and the distribution of quantum dots in rats.Methods Six rats underwent quantum dots injection at the subcutaneous of upper limbs while the other six rats underwent physiological saline injection at the same sites. Two weeks observation and postobservation dissection were done on all of the twelve rats to confirm if there were any abnormities. The distribution of quantum dots was measured by inductively coupled plasma-mass spectrometry. Results No apparent toxicity was seen during two weeks' observation. The results of Cadmium assay showed that quantum dots mainly accumulated in the livers, spleens and kidneys of the rats. Conclusions The toxicity of quantum dots can be affected by many factors, which remain further research.关键词
量子点(Qdots)/急性毒性/电感耦合等离子体质谱仪Key words
Quantum dots/ Acute toxicity/ Inductively coupled plasma-mass spectrometry分类
生物科学引用本文复制引用
孙鹏,李鹏,张旭瑞,乔伟伟,赵霞,张云鹏..量子点的急性毒性及动力学初步观察[J].实验动物与比较医学,2011,31(4):255-258,4.基金项目
国家自然科学基金(No.20874015) （No.20874015）
上海市科委纳米专项基金(No.1052nm03802) （No.1052nm03802）
