生殖医学杂志2011，Vol.20Issue(4)：275-279,5.DOI:10.3969/j.issn.1004-3845.2011.04.006
注射人绒毛膜促性腺激素与否对体外受精周期中改行未成熟卵体外培养结局的影响
Effect of hCG administration on the outcome of in vitro maturation converted from in vitro fertilization
王真 1赵军招 1王佩玉 1金聪聪 1林金菊 1张巍 1叶碧绿1
作者信息
- 1. 温州医学院附属第一医院生殖中心,温州,325000
- 折叠
摘要
Abstract
Objective: To investigate the effectiveness of human chorionic gonadotropin (hCG) administrated before oocytes retrieved on the outcome of in vitro maturation (IVM) converted from conventional IVF (C-IVF) cycles.Methods: We retrospectivly analyzed the data of 138 sterile women who underwent IVM converted from C-IVF cycles in this center from Jan.2008 to Nov.2010.The condition of IVM converted from C-IVF was that the developed oocytes were more than 20 after 5-7 days of ovulation induction, or follicular development was retarded and the oocyes were more than 15 after 8-13 days of ovulation induction, and the patients’ informed consent was obtained.In 138 cycles, there were 63 cycles with hCG administration 12 hours before oocytes retrieved (group A) and 75 cycles without hCG (group B).The laboratory test results and pregnancy outcomes were observed and compared.Results: In group A, the rate of maturation (64.56％) was significantly higher than that in group B (56.3％), but the mean number of oocytes retrieved (8.42±0.52) were significantly lower than that in group B (11.32±0.82) (P＜0.05).There was no significant difference in rates of fertilization, cleavage, excellent quality embryos, transplantation, clinical pregnancy, multiple pregnancy or transfered cycles between the two groups (P＞0.05).Conclusions: The program of IVM converted from C-IVF obtained a satisfactory outcome.The hCG administration before oocytes retrieved enhanced the rate of maturation, but did not improve the pregnancy outcome.关键词
体外受精/未成熟卵母细胞/体外培养/人绒毛膜促性腺激素Key words
In vitro fertilization/ Immature oocytes/ In vitro culture/ Human chorionic gonadotrophin引用本文复制引用
王真,赵军招,王佩玉,金聪聪,林金菊,张巍,叶碧绿..注射人绒毛膜促性腺激素与否对体外受精周期中改行未成熟卵体外培养结局的影响[J].生殖医学杂志,2011,20(4):275-279,5.
