生殖医学杂志2011，Vol.20Issue(4)：290-294,5.DOI:10.3969/j.issn.1004-3845.2011.04.010
促性腺激素释放激素拮抗剂方案中废弃胚胎发育潜能及其与妊娠结局的关系
The developmental potential of discarded embryos collected from GnRH antagonist ovarian stimulation protocols and its correlation with pregnancy outcome
郭情情 1李蓉 1郝桂琴 1耿岚 1付敏 1王娟娟1
作者信息
- 1. 北京大学深圳医院生殖医学科,深圳,518036
- 折叠
摘要
Abstract
Objective: To explore the developmental potential of discarded embryos collected from GnRH antagonist ovarian stimulation protocols, and its correlation with the pregnancy outcome.Methods: A total of 76 patients undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycle (group A: 47 patients with GnRH-agonist ovarian stimulation protocols; group B: 29 patients with GnRH-antagonist ovarian stimulation protocols) were investigated. Two hundreds and seventy four discarded embryos (including abnormally fertilized embryos) collected from these patients were cultured to allow blastula formation, which resulted in 4 subgroups (group A1: patients with blastocyst formation in group A; group A2: patients without blastocyst formation in group A; group B1:patients with blastocyst formation in group B; group B2: patients with blastocyst formation in group B).The blastula formation and the pregnancy outcome in different groups were observed and compared.Results: The patients' condition and clinical characteristics in the two groups were similar. The thickness of endometrium in group A was thicker than in group B at the day of oocytes retrieved. The duration of stimulation in group A was shorter than in group B (P＜0.01). The blastula formation rate was similar between group A and B (P＞0.05). Biochemic pregnancy rate of group A was higher than that of group B (P＜0.05). The clinical pregnancy rate of group A was significantly higher than that of group B (P＜0.01). Biochemical pregnancy rate and clinical pregnancy rate of group A1 were higher than those of group B1 or A2 (P＜0.05). The pregnancy rates of group B1 and B2 were similar (P＞0.05).Conclusions.. The discarded embryos had developmental potential at different degrees. GnRH-antagonist had no additional effect on the development potential of discarded embryos over GnRH-agonist.The developmental potential of discarded embryo was significantly associated with successful pregnancy outcome in GnRH-agonist ovarian stimulation protocols. The pregnancy rate of GnRH-antagonist ovarian stimulation protocols was lower than that of GnRH-agonist protocols. The reasons need further investigation.关键词
废弃胚胎/囊胚/促性腺激素释放激素激动剂/促性腺激素释放激素拮抗剂Key words
Discarded embryos/ Blastocyst/ GnRH-agonist/ GnRH-antagonist引用本文复制引用
郭情情,李蓉,郝桂琴,耿岚,付敏,王娟娟..促性腺激素释放激素拮抗剂方案中废弃胚胎发育潜能及其与妊娠结局的关系[J].生殖医学杂志,2011,20(4):290-294,5.
