生殖医学杂志2011，Vol.20Issue(4)：309-312,4.DOI:10.3969/j.issn.1004-3845.2011.04.014
早期自然流产蜕膜组织细胞凋亡与热休克蛋白70、P53的表达
Apoptosis and expressions of heat shock protein 70 and P53 in decidual tissues of early spontaneous abortion
郭燕 1王玉贤1
作者信息
- 1. 山西医科大学第一临床医院妇产科,太原,030001
- 折叠
摘要
Abstract
Objective: To investigate the relationship between the apoptosis and expressions of heat shock protein70 (HSP70) and P53 in decidual tissue of early spontaneous abortion. Methods: The decidual tissue samples were obtained from 20 cases of surgical aspiration of early pregnancy and 20 cases of early spontaneous abortion. Apoptosis was detected with terminal deoxynucleotidyl transferas-mediated dUTP-biotin nick ending labeling(TUNEL). Expressions of Hsp70 and P53 proteins were detected with immunohistochemistry. Results: The apoptosis indices decreased in decidual tissue of spontaneous abortion than that of surgical aspiration (P ＜ 0. 01). Hsp70 and P53 expressions were decreased in decidual tissue of spontaneous abortion than those of surgical aspiration (P＜0. 01). Conclusions: Abnormal apoptosis in decidual tissue might be one of the mechanisms of early spontaneous abortion. Increased apoptosis in decidual tissue of early spontaneous abortion was coincident with the up-regulation of expression of Hsp70. The higher expression of Hsp70 could not suppress apoptosis in decidua.关键词
流产/蜕膜/凋亡/热休克蛋白70/P53Key words
Abortion/ Decidua/ Apoptosis/ Heat shock protein 70/ P53引用本文复制引用
郭燕,王玉贤..早期自然流产蜕膜组织细胞凋亡与热休克蛋白70、P53的表达[J].生殖医学杂志,2011,20(4):309-312,4.
