化工学报2011，Vol.62Issue(7)：2080-2085,6.DOI:10.3969/j.issn.0438-1157.2011.07.044
T型微通道内丙酸倍氯米松纳米颗粒的制备
Preparation of beclomethasone dipropionate nanoparticles in T-junction microreactor
摘要
Abstract
As model drug, beclomethasone dipropionate (BDP) nanoparticles were prepared by using the antisolvent precipitation method in a T-junction microchannel. The influence of surfactant on particle morphology, as well as the influences of surfactant concentration, BDP solution flow rate, antisolvent flow rate, BDP solution concentration and precipitation temperature on particle size were explored. The results indicated that the morphology of BDP was spherical with the addition of surfactant (HPMC). Besides, the particle size decreased with decreasing BDP solution flow rate, increasing antisolvent flow rate and decreasing precipitation temperature. However, with the increase of BDP concentration, particle size reached a minimum. BDP nanoparticles with an average size of 200-260 nm and narrow size distribution could be prepared under the following conditions: BDP solution flow rate of 4 ml· min-1, antisolvent flow rate of 80 ml · min-1 , solution concentration of 0.03 g · ml-1. Furthermore, crude BDP and nanosized BDP were characterized by scanning electronic microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectrophotometry (FTIR), and surface area analyzer. The results showed that the precipitated BDP without HPMC was crystalline while the precipitated BDP with HPMC was completely amorphous. In addition, the as-prepared BDP had the same molecular structure as raw drug, and had a specific surface area 2 times as high as that of raw drug. T-junction microchannel would become a high-efficiency, low-cost technology platform of preparing nanodrugs.关键词
纳米药物/T型微通道/反溶剂重结晶法/丙酸倍氯米松/吸入型药物Key words
nanodrugs/ T-junction microchannel/ antisolvent precipitation/ beclomethasone dipropionate/ inhaled drug分类
化学化工引用本文复制引用
张乾霞,崔改静,周月,娄金婷,王洁欣..T型微通道内丙酸倍氯米松纳米颗粒的制备[J].化工学报,2011,62(7):2080-2085,6.基金项目
国家自然科学基金项目(20806004) （20806004）
国家高技术研究发展计划项目(2009AA033301). （2009AA033301）
