史琳 1张安文 1罗宇 1任占平 2杨燕初 1罗殿中3
作者信息
- 1. 柳州医学高等专科学校病理教研室,广西,柳州,545005
- 2. 柳州市人民医院病理科,广西,柳州,545006
- 3. 广西医科大学病理教研室,广西,南宁,530021
- 折叠
摘要
Abstract
Objective To investigate the expression of MCM7 and p27 in thyroid carcinoma and its clinical significance. Methods Immunohisteohemical S-P method was used to detect the expressions of MCM7 and p27 protein in 50 cases of thyroid carcinoma,30 cases of thyroid adenoma,30 cases of nodular goiter and 20 specimens of normal thyroid tissue. Results The positive rates of MCM7 expression in thyroid carcinoma, thyroid adenoma, nodular goiter and normal thyroid tissue were 100.0％ (50/50), 20. 0％ ( 6/30 ),23.3％ (7/30), 20％ (4/20), respectively. The expression of MCM7 protein in thyroid carcinoma was significantly higher than that in thyroid adenoma,nodular goiter and normal thyroid tissue (P ＜0.01 ,P ＜0.01 ,P ＜0. 01 ). The positive rates of p27 expression in thyroid carcinoma,thyroid adenoma,nodular goitre and normal thyroid tissue were 22.0％ (11/50) ,100.0％ (30/30), 100.0％ (30/30) and 100.0％ (20/20), respectively. The expression of p27 protein in thyroid carcinoma was significantly lower than that in thyroid adenoma,nodular goiter and normal thyroid tissue (P ＜0.01 ,P ＜0.01 ,P ＜0.01 ).A negative correlation was observed between the expressions of MCM7 and p27 protein in thyroid carcinoma tissue ( r = - 0. 326, P ＜ 0. 01 ). Conclusions The high expression of MCM7 protein and low expression of p27 protein in thyroid carcinoma may be involved in the progression and development of thyroid carcinoma. Combined examination of MCM7 and p27 proteins may be used for early diagnosis of thyroid carcinoma.关键词
甲状腺肿瘤/病理学/甲状腺肿瘤/代谢/微丝蛋白质类/生物合成/腺瘤/代谢/腺瘤/病理学/染色体/基因表达/免疫组织化学Key words
thyroid neoplasms/pathology/ thyroid neoplasms/metabolism/ microfilaent proteins/biosynthesis/ adenoma/ metabolism/ adenoma/pathology/ chromosomes/ gene expression/ immunohistochemistry分类
医药卫生
