解放军医学杂志2011，Vol.36Issue(8)：839-842,4.
172例晚发型重症肌无力患者的临床特点及疗效分析
Clinical characteristics of late-onset myasthenia gravis in 172 patients and analysis of treatment effect
王卫 1魏东宁 1陈玉萍 1王中魁1
作者信息
- 1. 100091,北京,解放军309医院神经内科
- 折叠
摘要
Abstract
Objective To analyze the clinical characteristics of late-onset myasthenia gravis (MG), and explore the therapeutic effects of different therapeutic regimens for MG.Methods The clinical data of 172 patients (95 males and 77 females) with late-onset (age of onset≥50) MG were analyzed, including sex ratio, initial symptoms, clinical classification and type of pathology of the thymus.Four therapeutic regimens were carried out in patients respectively, comprising acetylcholinesterase inhibitor alone, acetylcholinesterase inhibitor plus corticosteroid, acetyleholinesterase inhibitor plus immunosuppressive agents, and conventional therapy plus thymectomy.The therapeutic effects of each regimen were evaluated 6-24 months after treatment.Results Of the 172 patients with late-onset MG, 85 (49.4％) were classified as clinical type of IIB, with the main initial symptom mainly involving extraocular muscles (87.8％), and thymoma (44.6％) and hyperplastic thymus (52.7％) were the major pathological types.A favorable effect (94.9％) was achieved in MG patients with onset age of 50 to 59 years, while the poorest result (69.7％) was seen in those with onset age of 60 to 69 years (P＝0.0044).Conclusion The majority of late-onset MG patients presented severe symptoms.The incidence of hyperplastic thymus is similar to that of thymoma, and the therapeutic effects are correlated with the onset age of MG patients.关键词
重症肌无力,晚发型/治疗方案/疗效Key words
myasthenia gravis/ late-onset/ clinical protocols/ treatment outcome分类
医药卫生引用本文复制引用
王卫,魏东宁,陈玉萍,王中魁..172例晚发型重症肌无力患者的临床特点及疗效分析[J].解放军医学杂志,2011,36(8):839-842,4.
