中国临床心理学杂志2011，Vol.19Issue(4)：430-432,3.
首发抑郁症患者海马容积与磁共振波谱的研究
Volume Change of Hippocampus and Changes of 1H-MRS in Patients with Major Depression
摘要
Abstract
Objective: To explore the volume change in hippocampus and the relationship between changes of 1HMRS in patients with major depression.Methods: 50 patients with major depression and 50 gender-and age-mathed normal controls were involved.The volume of hippocampus were standardized by division method, and then compared with the ratios of N-acetylaspartic acid (NAA)/(creatine) Cr and choline (Cho)/Cr.Results: The volume of hippocampus in all patients with depression was changed compared with the controls, 31 severe ones were significant smaller than that in controls (P＜0.05).The values of NAA/Cr ratios were significant lower in severely depressed patients than that in controls (P＜0.01).The degree of hippocampus volume narrow was positively related with the values of NAA/Cr ratios reduction.Conclusion: These findings support the hypothesis that N-acetylaspartic acid in hippocampus may play an essential role in the development of major depression.关键词
抑郁症/海马/磁共振波谱学/对比研究Key words
Depression/ Hippocampus/ Magnetic resonance spectroscopy/ Comparative study分类
医药卫生引用本文复制引用
蒋湘玲,陈旺生,郭敏..首发抑郁症患者海马容积与磁共振波谱的研究[J].中国临床心理学杂志,2011,19(4):430-432,3.基金项目
2008年国家自然科学基金(30860082) （30860082）
2009年海南省重点科技项目(090209) （090209）
2010年海南省重点科技项目(zdxm20100043) （zdxm20100043）
