临床肝胆病杂志2011，Vol.27Issue(8)：881-884,4.
乙型肝炎病毒感染与肝细胞癌DNA甲基化研究进展
Hepatitis B virus infection and DNA methylation in hepatocellular carcinoma
熊启香 1熊莉娟1
作者信息
- 1. 华中科技大学同济医学院附属协和医院感染科,武汉,430022
- 折叠
摘要
Abstract
The persistent and chronic HBV infection is a main risk factor of hepatocarcinogenesis. The recent studies reported that epigenetics, especially the hypermethylation of CpG islands of the tumor suppressor gene, played an important role in hepatocarcinogenesis, and epigenetic changes appeared in the early stage of tumor formation. Methylation in HCC occured in a gene - specific and cancer - specific manner. It may be benefit to the early diagnosis and prognosis assessment. Here we review current opinions about hypermethylation of tumor suppressor gene induced by HBV infection.关键词
肝炎,乙型,慢性/癌,肝细胞/肝炎病毒,乙型/DNA甲基化Key words
hepatitis B/ chronic/ carcinoma/ hepatocellular/ hepatitis B virus/ DNA methylation分类
医药卫生引用本文复制引用
熊启香,熊莉娟..乙型肝炎病毒感染与肝细胞癌DNA甲基化研究进展[J].临床肝胆病杂志,2011,27(8):881-884,4.
