实用医学杂志2011，Vol.27Issue(14)：2539-2541,3.DOI:10.3969/j.issn.1006-5725.2011.14.021
重组人血管内皮抑素联合经皮肝动脉化学栓塞术治疗中晚期原发性肝癌
Recombinant human endostatin combined with transcatheter arterial chemoembolization for treatment of advanced hepatocellular carcinoma
摘要
Abstract
Objective To investigate the efficacy and safety of combined therapy of recombinant human endostatin plus transcatheter arterial chemoembolization (TACE) for advanced hepatocellular carcinoma.Methods Sixty patients with advanced hepatocellular carcinoma were equally and randomly divided into study group and control group. Patients in study group received the combined therapy of endostatin plus TACE, while patients in control group received conventional TACE only. After the combined therapy, the overall response rate (CR+PR), the value of alpha-fetoprotein (AFP), the 1-year and the 2-year survival rates were surveyed and assessed.The adverse effects were compared between the two groups. Results Compared with the control group, the overall response rates of the study group were markebly higher (x2= 4.286 ,P ＜ 0.05). The AFP level improved cases and AFP level stable cases of the study group and the control group were 17,10 and 10,14. The median survival was 14.1 months (6.3 to 24.0 months) in the study group and 9.8 months (5.7 to 24.0 months) in the control group. The 1-year and 2-year survival rates of the study group and the control group were (83.3 ±3.5)％、 (40.0 ± 6.1 )％and (60.0 ± 3.4)％、 (30.0 ± 7.3)％.The 1-year survival rates between the two groups has a statistical significance (P＜0.05 ), while the 2-year survival rates not (P ＞ 0.05 ). No obvious adverse effects were observed in the two groups. The incidence of endostatin side effects were not much difference between the two different administration methods.Conclusion The treatment of endostatin plus TACE for advanced hepatocellular carcinoma demonstrated a better short-term curative effect with fewer side-effects, and is worthy of clinical generalization.关键词
肝肿瘤/血管内皮抑素/肝动脉灌注治疗Key words
Endostatin/ Transcatheter arterial chemoembolization/ Liver neoplasm Treatment引用本文复制引用
吴梨华,吴建兵,余志宏,廖新根,熊强..重组人血管内皮抑素联合经皮肝动脉化学栓塞术治疗中晚期原发性肝癌[J].实用医学杂志,2011,27(14):2539-2541,3.基金项目
江西省教育厅课题(编号:赣教技字[GJJ08073]号) （编号:赣教技字[GJJ08073]号）
