中国比较医学杂志2011，Vol.21Issue(7)：55-58,后插3,5.DOI:10.3969/j.issn.1671.7856.2011.07.012
瘦素和转化生长因子β1在大鼠肝纤维化过程中的作用
Effect of Leptin and Transforming Growth β《,1》 during Experimental Hepatic Fibrosis
宋维芳 1徐军全 1马丽英 2连小娟 2王明亮 1郭明清2
作者信息
- 1. 山西医科大学汾阳学院病理生理学教研室,汾阳,032200
- 2. 山西省汾阳医院感染科肝病区,汾阳,032200
- 折叠
摘要
Abstract
Objective To explore the effect of leptin and transforming growth β1 in fibrosis liver. Methods The female Wistar rats were randomly divided into normal control group and four model groups( 1 week , 2 week , 4 week , 6 week). Carboan tetrachloride was injected for establishing hepatic fibrosis model in model groups. The levels of leptin and transforming growth β1 were determined . The pathological hepatic changes were observed by HE. The degree of liver fibrosis was observed by stained of sirius red of collagen and the content of hydroxyproline in liver tissues, and the relationship with leptin and transforming growth β1 and FI were amalyzed. The ALT of serum was mensurated with laishi method. Results Compared with control group, the expression of leptin and transforming growth β1 increased significantly in liver fibrosis group ( P ＜ 0. 05 ). The expression of leptin and transforming growth β1 in liver tissue were correlated positively with FI in liver fibrosis group. Conclusions The results of the study demonstrate increased leptin and transforming growth β1 levels of liver tissue in liver fibrosis model groups, and activating leptin may up-regulate the expression of transforming growth β1 during experimental hepatic fibrosis.关键词
瘦素/转化生长因子β1/肝纤维化Key words
Leptin/ Transforming growth β1/ Hepatic fibrosis分类
医药卫生引用本文复制引用
宋维芳,徐军全,马丽英,连小娟,王明亮,郭明清..瘦素和转化生长因子β1在大鼠肝纤维化过程中的作用[J].中国比较医学杂志,2011,21(7):55-58,后插3,5.
