中国动脉硬化杂志2011，Vol.19Issue(7)：561-564,4.
载脂蛋白C Ⅲ基因多态性与汉族男性血脂的关系
Relationship Between Apolipoprotein CⅢ Gene Polymorphism and the Levels of Serum Lipids in Male
摘要
Abstract
Aim To explore the relationship between apolipoprotein C Ⅲ (ApoC Ⅲ ) gene C3175G, T3206G polymorphism and the levels of serum lipids in male, as well as the multiple risk factors of overweight-obesity.Methods A total 337 males were selected from two hospitals by using DNA sequencing ,and the apolipoprotein CⅢ gene C3175G,T3206G polymorphism and the serum lipids were determined and analyzed their relationships were analyzed.Results The genotype frequencies of the CC, CG and GG for ApoCⅢ3175 were 51.93％ ,40.06％ and 8.01％, respectively, and C allele was 71.9％ and G allele was 28.04％.The frequencies of TT, TG and GG for ApoC Ⅲ 3206 were 6.82％,32.34％ and 60.83％, respectively, and T was 23.0％ and G was 77.0％.The carriers of ApoC Ⅲ3157G could have the higher level of triglyceride (TG).According to stratified selection of TG, there were relationships between APoC Ⅲ and TC/LDLC.The mμltiple linear regression showed that abdomen obesity and ApoCⅢC3157G polymorphism might be associated with TG.Conclusion The ApoC Ⅲ C3157G is related to the levels of serum TG and the results were supported the relationships between ApoC Ⅲ T3206G and TC/LDLC in population with high TG.关键词
载脂蛋白CⅢ/基因多态性/血脂Key words
ApoC Ⅲ gene/ Polymorphism/ Serum Lipids分类
医药卫生引用本文复制引用
唐晓君,唐敏,张阳丹,张名均,戴勇..载脂蛋白C Ⅲ基因多态性与汉族男性血脂的关系[J].中国动脉硬化杂志,2011,19(7):561-564,4.基金项目
广东省科技厅项目(2003C30609) （2003C30609）
重庆市教委自科项目(编号KJ070313) （编号KJ070313）
