中国动脉硬化杂志2011，Vol.19Issue(9)：727-730,4.
桂枝汤对高脂血症心肌缺血大鼠血管活性物质的影响
Influence of Guizhi Tang on Vascular Endothelial Active Substance in Rat with Experimental Hyperlipemia and Myocardial Ischemia
摘要
Abstract
Aim To explore the influence of Guizhi Tang to vascular endothelial active substances in rats with experimental hyperlipemia and myocardial ischemia.Methods The early changes of hyperlipid and atherosclerosis were caused by utilizing multiple factors including feeding hyperlipid, propylthiouracil and high doses of VD3.Based on the above, the myocardial ischemia model was established by injecting high doses of pituitrin.The total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDLC) and low density lipoprotein cholesterol (LDLC) were measured in the 6th, 12nd and 18th week respectively, and also the content of endothelin (ET), 6-ketoprostaglandin F1 alpha (6-keto-PGF1α), thromboxane B2(TXB2) and angiotensin Ⅱ (AngⅡ) were determined.Results Guizhi Tang significantly improves the indexes of blood lipid metabolism, decreases TC, TG and LDLC, and increases HDLC.Guizhi Tang decreases ET, Ang Ⅱ and TXB2 of blood serum, and increases 6-keto-PGF1α.Conclusion Guizhi Tang can regulate the function of vasoactive substance, protect endothelial cell and inhibit the formation of atherosclerosis.关键词
冠心病(胸痹)/心肌缺血/桂枝汤/高脂血症/血管内皮活性物质Key words
Coronary Heart Disease (Chest Impediment)/ Myocardial Ischemia/ Guizhi Tang/ Hyperlipemia/ Vascular Endothelial Active Substance分类
医药卫生引用本文复制引用
焦宏,孙琳,陈彦静,鞠大宏,杜会博,马建伟,薛贵平,侯勇..桂枝汤对高脂血症心肌缺血大鼠血管活性物质的影响[J].中国动脉硬化杂志,2011,19(9):727-730,4.基金项目
河北省中医药管理局项目(2008103) （2008103）
