中国临床药理学与治疗学2011，Vol.16Issue(6)：652-656,5.
强的松及万汶对中、重度卵巢过度刺激综合征预防作用的比较
Comparison of prednisone versus hydroxyethylstarch for prevention of moderate and severe ovarian hyperstimulation syndrome
杨海燕 1赵军招 1林文琴 1林金菊 1余蓉1
作者信息
- 1. 温州医学院附属第一医院生殖中心,温州325027,浙江
- 折叠
摘要
Abstract
AIM: To compare the efficiency of prednisone and 6％ hydroxyethylstarch in the prevention of moderate and severe ovarian hyperstimulation syndrome (OHSS). METHODS:A total of 207 OHSS high-risk patients and 207 cycles of in vitro fertilization and embryo transfer (IVF-ET) programme with estradiol serum concentration≥4000 pg/mL on the day of hCG injection and/or≥l5 oocyte collection were prospective and randomized divided into A, B and C three groups. The patients in group A (66 cycles) orally took prednisone 5 mg fid on the day of hCG injection for 2 d, and then changed to 5 mg qd for 5 d; the patients in group B (75 cycles) were infused with 500 mL 6％ hydroxyethylstarch on the day of oocyte collection for 3d;the patients in group C (66 cycles) were treated with prednisone and hydroxyethylstarch. The incidence of moderate and severe OHSS and the other corresponding indexes among the three groups were analyzed. RESULTS: There have 60 cycles were transferred in group A, clinical pregnancy rate was 50％ and the incidence of moderate and severe OHSS was 3.03％; 65 cycles were transferred in group B, clinical pregnancy rate was 44. 6％ , and the incidence of moderate and severe OHSS was 13.33％; 59 cycles were transferred in group C, clinical pregnancy rate was 42.4 ％ and the incidence of moderate and severe OHSS was 3.03％ . There was no significant difference in pregnancy outcome among the three groups (P＞0.05), but the incidence of moderate and severe OHSS in group B was higher than those in group A and group C (P＜0.05). CONCLUSION: Oral administration of prednisone have no effect on pregnant rate of IVF and it is a cheaper, more convenient and effective alternative to 6％ hydroxyethylstarch in moderate and severe OHSS prevention.关键词
体外受精-胚胎移植/卵巢过度刺激综合征/强的松/万汶Key words
In vitro fertilization/ Ovarian hyperstimulation syndrome/Prednisone /Hydroxyethylstarch分类
医药卫生引用本文复制引用
杨海燕,赵军招,林文琴,林金菊,余蓉..强的松及万汶对中、重度卵巢过度刺激综合征预防作用的比较[J].中国临床药理学与治疗学,2011,16(6):652-656,5.
