中国临床药理学与治疗学2011，Vol.16Issue(6)：657-660,4.
静脉丙种球蛋白无反应性川崎病的危险因素分析
Analysis of risk factors with refractory Kawasaki disease to gamma-globulin therapy
张松跃 1张园海 1荣星 1任跃 1陈其 1项如莲1
作者信息
- 1. 温州医学院附属第二医院小儿心血管科,温州325027,浙江
- 折叠
摘要
Abstract
AIM: To investigate the incidence and risk factors of children with refractory Kawasaki disease (KD). METHODS: Clinical data of KD patients hospitalized in the Second Affiliated Hospital of Wenzhou Medical College from January 2005 to December 2010 were summarized. Refractory KD was defined as those who remained febrile with a temperature of ＞ 38. 5 C for 36 hours after initial intravenous immunoglobulin treatment. All KD patients were divided into two groups, responsiveness group and non-responsiveness group, based on their response to the first high dose IVIG therapy. RESULTS:Total 51S KD patients treated with high dose IVIG were included. The incidence of nonresponsiveness to IVIG therapy is 7.57％ (39/ 515). Logistic regression revealed that white blood cell (WBC), hemoglobin, C-reactive protein ( CRP ), erythrocyte sedimentation rate (ESR), alanine aminotransferase (ALT), serum albumin and IVIG dosage were independent risk factors for refractory KD(P＜0.05). CONCLUSION: The incidence of refractory KD is 7.57％. WBC, hemoglobin, CRP, ESR, ALT,serum albumin and IVIG dosage can predict the occurrence of refractory KD.关键词
川崎病/丙种球蛋白/静脉注射/无反应/危险因素Key words
Kawasaki disease/ Gamma globulin/ Intravenous injection/ Non-responsiveness/ Risk factor分类
医药卫生引用本文复制引用
张松跃,张园海,荣星,任跃,陈其,项如莲..静脉丙种球蛋白无反应性川崎病的危险因素分析[J].中国临床药理学与治疗学,2011,16(6):657-660,4.
