中国临床药理学与治疗学2011，Vol.16Issue(6)：672-678,7.
内源性睡眠促进物质研究进展
Endogenous sleep-promoting substances
摘要
Abstract
Sleep-wake cycle is regulated by humoral and neuronal mechanism, as well as circadian rhythm. Kuniomi Ishimori and Henri Piéron provided the first experimental evidence for chemical factors that presumably accumulate in the cerebrospinal fluid in dogs after sleep deprivation, and eventually induce sleep. These substances are named hypnotoxin. Accumulated findings show that these endogenous substances include prostanoids, nucleotides, cytokines,neuropeptides, hormones, amine derivatives, nitrogen oxide and so on. This paper presents an overview of current knowledge about the roles of endogenous sleep-promoting substances in the sleep-wake regulation with a focus on prostaglandin D2, adenosine, interleukin-1, and tumor necrosis factor.关键词
内源性睡眠促进物质/前列腺素D2/腺苷/细胞因子Key words
Endogenous sleep-promoting substances/ Prostaglandin D2/ Adenosine/ Cytokines分类
医药卫生引用本文复制引用
岳小芳,邱梅红,曲卫敏,黄志力..内源性睡眠促进物质研究进展[J].中国临床药理学与治疗学,2011,16(6):672-678,7.基金项目
国家自然科学基金(30625021、30821002、30970955、31070957) （30625021、30821002、30970955、31070957）
"重大新药创制"科技重大专项(2009ZX09303-006) （2009ZX09303-006）
上海市科学技术委员会基金(09PJ1401800、09JC1402500、10XD1400400、10441901600、11ZR1401800)和上海市重点学科建设项目基金(B119) （09PJ1401800、09JC1402500、10XD1400400、10441901600、11ZR1401800）
