中国临床药理学与治疗学2011，Vol.16Issue(6)：699-709,11.
人体关键药代动力学参数预测方法
Prediction of key pharmacokinetic parameters in human
摘要
Abstract
Volume of distribution, clearance,half of life and bioavailability are crucial pharmacokinetic parameters determining the extent and sustained time of drugs exposed in vivo. Thus,in the stage of drug discovery and development,it is of particular interest to estimate the pharmacokinetic parameters of drug candidates in human as early as possible to select the most promising compounds for further development. This paper reviews recent developments in prediction of human key pharmacokinetic parameters based upon preclinical animal pharmacokinetic data,absorption and metabolism data in vitro, physico-chemical property and in silico prediction.关键词
预测/药代动力学参数/体外-体内相关性Key words
Prediction/ Pharmacokinetic parameters/ In vitro-in vivo correlation分类
医药卫生引用本文复制引用
祝建平,孙建国,彭英,王广基..人体关键药代动力学参数预测方法[J].中国临床药理学与治疗学,2011,16(6):699-709,11.基金项目
中央高校基本科研业务费专项资助(JKP2009007) （JKP2009007）
国家自然科学基金(30901832) （30901832）
"十一五"重大新药创制项目资助(2009ZX09304-001) （2009ZX09304-001）
