南方医科大学学报2011，Vol.31Issue(7)：1138-1141,4.
脑干和杏仁中央核的谷氨酸能神经元参与甜味觉的传递与调制
Glutaminergic neurons expressing c-Fos in the brainstem and amygdala participate in signal transmission and integration of sweet taste
摘要
Abstract
Objective To examine the role of glutaminergic neurons in the transmission and integration of the sweat taste information in the brain stem and the amygdala. Methods Conscious Sprague-Dawley rats were subjected to oral sweet taste or water (control) stimulations. The activated neurons were identified by detecting c-Fos expression in taste-related brain areas, and the glutaminergic neurons by detecting vesicular glutamate transpoter-3 (VGLUT3). Results Compared with control group, the rats with oral sucrose solution stimulation exhibited significantly increased c-Fos-expressing and double-labeled neurons in the nucleus of the solitary tract (NST), the parabrachial nucleus (PBN) and the amygdala. Conclusion Neurons in the NST, PBN and amygdala are activated after oral sweet taste stimulation. The sweet taste perception at different levels in the CNS is partly mediated by glutamate.关键词
甜味觉/谷氨酸/孤束核/臂旁核/杏仁中央核/c-FosKey words
sweet taste/glutamate/nucleus of the solitary tract/parabrachial nucleus/central nucleus of the amygdala/c-Fos分类
医药卫生引用本文复制引用
赵小林,闫剑群,陈坷,杨雪娟,李金容,张嫄..脑干和杏仁中央核的谷氨酸能神经元参与甜味觉的传递与调制[J].南方医科大学学报,2011,31(7):1138-1141,4.基金项目
国家自然科学基金(30970973 （）
31000518) （）
陕西省自然科学基础研究计划(2010JQ4001) （2010JQ4001）
