南方医科大学学报2011，Vol.31Issue(7)：1200-1203,4.
槲皮素对成年大鼠局灶性脑缺血后侧脑室室管膜下区神经干细胞增殖的影响
Effect of quercetin on neural stem cell proliferation in the subventricular zone of rats after focal cerebral ischemia-reperfusion injury
摘要
Abstract
Objective To study the effect of quercetin on the proliferation of neural stem cells in the subventricular zone (SVZ) of rats after focal cerebral ischemia. Methods An adult rat model of middle cerebral artery occlusion (MCAO) model was established by placement of an intraluminal filament at the origin of the MCA. Quercetin was administered intraperitoneally in the rats at a dose of 50 mg/kg every 3 days starting at 6 h after MCAO, and BrdU (50 mg/kg daily) was also injected intraperitoneally starting at 4 h after MCAO. BrdU-positive cells in the SVZ were counted at 7, 14 and 21 days after MCAO. Results Compared with the sham-operated group, the rats in the ischemic model group showed significantly increased BrdU-positive cells in the ipsilateral SVZ 7 days after MCAO, reaching the peak level on day 14 and beginning to decrease on day 21 (P<0.05). The number of ipsilateral BrdU-positive cells in quercetin group was significantly greater than that in the model group on days 7,14 and 21 (P<0.05), and maintained the high level on day 21. Conclusion Quercetin can maintain a high level of neural stem cell proliferation in the SVZ after focal cerebral ischemia in adult rats.关键词
槲皮素/侧脑室/室管膜下区/细胞增殖/脑缺血Key words
quercetin/lateral ventricle/subventricular zone/cell proliferation/cerebral ischemia分类
医药卫生引用本文复制引用
张兰兰,曹琼,胡子有,颜晓慧,吴炳义..槲皮素对成年大鼠局灶性脑缺血后侧脑室室管膜下区神经干细胞增殖的影响[J].南方医科大学学报,2011,31(7):1200-1203,4.基金项目
国家自然科学基金海外青年学者合作研究基金(30628018) （30628018）
广东省"211工程""器官衰竭的防治研究"项目 （）
