南方医科大学学报2011，Vol.31Issue(7)：1216-1219,4.
食管鳞状细胞癌组织中肌动蛋白交联蛋白的表达和临床意义
Expression of fascin in human esophageal squamous cell carcinoma and its clinical significance
摘要
Abstract
Objective To investigate the role of fascin, an actin bundling protein, in the development and progression of human esophageal squamous cell carcinoma (ESCC), and explore its association with the clinicopathologic characteristics and 5-year survival of the patients. Methods Using tissue array and immunohistochemistry, the expression of fasdn was determined in 241 ESCC tissues and the corresponding normal esophageal mucosal tissues. Results ESCC tissues showed a significantly higher overexpression rate of fascin than the corresponding normal esophageal mucosal tissues (68.9% vs 15.5%, P<0.05). The overexpression of fascin was correlated to lymph node metastasis and TMN stage, but not to the patients' age, gender, tumor differentiation and general classification. Survival analysis showed that abnormal expression of fascin was associated with the 5-year survival rate of patients with ESCC. Conclusions The abnormal expression of fascin may play an important role in the progression of ESCC, and detection of fascin expression may have important prognostic values.关键词
食管鳞状细胞癌/肌动蛋白交联蛋白/组织芯片/5年生存率Key words
esophageal squamous cell carcinoma/fascin/tissue microarray/5-year survival rate分类
医药卫生引用本文复制引用
秦艳茹,汤虹,乔俊静,李芳芳,艾教育..食管鳞状细胞癌组织中肌动蛋白交联蛋白的表达和临床意义[J].南方医科大学学报,2011,31(7):1216-1219,4.基金项目
河南省博士基金(200703042) （200703042）
河南省卫生厅基金项目(201003025) （201003025）
