摘要
Abstract
Objective To study the distribution and drug-resistance of pathogens isolated from children with lower respiratory tract infections in a hospital. Methods Bacterial strains isolated from sputum specimens from February to September,2010 were identified and performed antimicrobial susceptibility test by VITEK2compact system. Results A total of 4 094 strains (34. 74％) were isolated from 11 785 sputum samples, 2 826 (69. 03％) of which were gram-negative bacilli, including 1 012 strains of Klebsiella pneumoniae, 574 Escherichia coli, 438 Acinetobacter baumannii, 221 Enterobacter cloacae, and so on; 1 167 (28. 50 ％ ) strains of gram-positive cocci were detected, including 402 strains of Staphylococcus aureus, 296 Streptococcus pneumoniae, and 193 Staphylococcus epidermidis; 101 (2. 47％) strains of fungi were also detected. Positive rate of extended-spectrum beta-lactamases in Klebsiella pneumoniae and Escherichia coli was 23. 91％ and 22. 13％, respectively; gram-negative bacilli were highly sensitive to imipenem, the resistant rate was between 0. 00％ - 2. 97％. 12. 19％ of Staphylococcus aureus,35.75％ of Staphylococcus epidermidis, and 47. 87％ of Staphylococcus haemolyticus were methicillin-resistant,these strains were highly sensitive to vancomycin, the resistant rate was 0. 00％. Eight strains (2. 70％) of Streptococcus pneumoniae were resistant to vancomycin, while sensitive to linezolid, the resistant rate was 0. 00％. Conclusion There are multidrug-resistant strains in children with lower respiratory tract infection, in order to reduce the emergence of drug resistant strain, antimicrobial agents should be used according to antimicrobial susceptibility test results.关键词
儿童/下呼吸道感染/病原菌/抗药性,微生物/超广谱β-内酰胺酶/耐甲氧西林葡萄球菌Key words
children/lower respiratory tract infection/pathogen/ drug resistance,microbial/ extended-spectrum β-lactamases/ methicillin-resistant Staphylococcus分类
医药卫生
