结直肠肛门外科2011，Vol.17Issue(3)：136-138,3.
CEA水平与进展期直肠癌新辅助放化疗疗效的关系
The value of CEA level in predicting tumor response after preoperative chemoradiotherapy for advanced rectal cancer
陈纲 1李世拥 1崔伟 1陈光1
作者信息
- 1. 北京军区总医院全军普通外科中心,北京,100700
- 折叠
摘要
Abstract
Objective To analyze pretreatment level of the serum carcinoembryonic antigen (CEA)that could predict tumor response to preoperative chemoradiotherapy(CRT) for advanced rectal cancer. Methods The study involving 48 patients who underwent preoperative CRT followed by surgery were divided into two groups:CEA normal group and CEA elevated group. Tumor responses to preoperative CRT were assessed in terms of tumor downstaging and tumor regression. Statistical analyses were performed to identify CEA level associated with tumor response. Results In CEA elevated group(2lcases) ,tumor downstaging (defined as ypT2 or less) was observed in 12 patients(57％ ), whereas tumor regression (defined as Dworak's Regression Grades 3 or 4 ) was observed in 11 patients ( 52％ ). In CEA normal group( 27 cases), tumor downstaging was observed in 20 patients( 74％ ), whereas tumor regression was observed in 21 patients (78 ％ ). Conclusion The data suggest that pretreatment CEA level is the important clinical predictor of tumor response after CRT. It may be of benefit in the selection of treatment options as well as the assessment of individual prognosis.关键词
直肠肿瘤/新辅助放化疗/肿瘤降期/肿瘤消退Key words
Rectal neoplasms/ Preoperative chemoradiotherapy /Downstaging/ Tumor regression分类
医药卫生引用本文复制引用
陈纲,李世拥,崔伟,陈光..CEA水平与进展期直肠癌新辅助放化疗疗效的关系[J].结直肠肛门外科,2011,17(3):136-138,3.
